Vilastobart (XTX101) Monotherapy and Vilastobart and Atezolizumab Combination Therapy in Advanced Solid Tumors

Inclusion Criteria:

Disease Criteria -

1. Part 1A and 1C: Any histologically or cytologically confirmed solid tumor malignancy that is locally advanced or metastatic and has failed standard therapy, or standard therapy is not curative or available;
2. Part 1B:

1. Any histologically or cytologically confirmed solid tumor malignancy for which anti-PD-1 or anti-PD-L1 treatment is approved and has progressed on or after prior anti-PD-1 or anti-PD-L1 therapy.
2. Patients with metastatic castrate-resistant prostate cancer if they have progressed on at least 2 lines of systemic therapy
3. Patients with extensive stage small cell lung cancer (SCLC) after at least 1 line of prior therapy
4. Patients with microsatellite stable colorectal cancer after at least 2 lines of prior therapy
5. Phase 2: Patients with histologically confirmed metastatic MSS CRC are eligible to enroll in Phase 2 as follows:

1. Patients must have had at least 1 prior chemotherapy regimen for metastatic CRC including all of the following agents: a fluoropyrimidine, irinotecan, oxaliplatin, bevacizumab or biosimilars, an anti epidermal growth factor receptor antibody (cetuximab or panitumumab), and v-raf murine sarcoma viral oncogene homolog B1 inhibitor/BRAF (encorafenib), if applicable
2. Patients with MSI-H/dMMR are excluded
3. ECOG performance status of 0 or 1
4. Adequate organ function
5. Part 1B, Part 1C, and Phase 2 only: measurable disease per iRECIST

Exclusion Criteria:

1. Received prior treatment with anti-CTLA-4 therapy
2. Received prior immune-checkpoint therapy and experienced Grade 3 or greater toxicity lasting greater than 6 weeks
3. Received prior systemic anticancer therapy within 4 weeks prior to study treatment
4. Received prior radiotherapy within 2 weeks prior to study treatment
5. Phase 2 only: Received prior anti-PD-1/L1 therapy or any investigational checkpoint inhibitory therapy
6. Has a diagnosis of immunodeficiency
7. Has known malignancy (other than disease under study) that is progressing or has required active treatment within the past 3 years
8. Has an active autoimmune disease that has required systemic treatment in past 2 years, including the use of disease modifying agents, corticosteroids or immunosuppressive drugs
9. Has an active infection requiring systemic intravenous therapy within 4 weeks prior to study treatment, or oral therapy within 2 weeks prior to study treatment
10. Has a history of severe hypersensitivity reaction (≥ Grade 3) to any study intervention and/or any of its excipients
11. Has a known psychiatric or substance abuse disorder that would interfere with the participant's ability to cooperate with the requirements of the study
12. Phase 2 only: symptomatic bowel obstruction