A Phase I Study of ERY974 in Patients With Hepatocellular Carcinoma
About the study
This is a multicenter, open-label, dose-escalation study designed to determine the maximum tolerated dose (MTD) by evaluating dose-limiting toxicities (DLTs) and to evaluate the safety, tolerability, pharmacokinetics, anti-tumor effect, and biomarkers of ERY974 in combination with atezolizumab and bevacizumab following premedication with tocilizumab in patients with locally advanced or metastatic HCC.
Who can take part
You may be eligible to participate in the study if you meet the following criteria:
INCLUSION CRITERIA
Inclusion Criteria:
- Aged ≥18 years at time of informed consent
- Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0 or 1
- HCC that has been histologically confirmed
EXCLUSION CRITERIA
Exclusion Criteria:
- Previous or concomitant autoimmune disease
- Uncontrolled diabetes mellitus and hypertension
- Concurrent New York Heart Association (NYHA) Class ≥II congestive heart failure, myocardial infarction, arrhythmia, or unstable angina, or a history thereof within 6 months before enrollment.
- Concurrent symptomatic cerebrovascular disorder (e.g., subarachnoid hemorrhage, cerebral infarction, or transient ischemic attack), or a history thereof within 6 months before enrollment.
- Symptomatic, untreated, or actively progressing CNS metastases
Study Locations
Enter your ZIP code/Postal code/PIN code to locate study sites near you:
How to Apply
Contact the study center to learn if this study is a good match for you.
Study Details
Contition
Hepatocellular Carcinoma (HCC)
Age
18+
Phase
PHASE1
Participants Needed
179
Est. Completion Date
Dec 31, 2025
Treatment Type
INTERVENTIONAL
Sponsor
Chugai Pharmaceutical
ClinicalTrials.gov NCT Identifier
NCT05022927
Study Number
ERY103JG
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