For Healthcare Professionals

Study of BGB-11417 in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

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About the study

The purpose of this study is to evaluate the efficacy of BGB-11417 in participants with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
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Who can take part

You may be eligible to participate in the study if you meet the following criteria:

INCLUSION CRITERIA

Key Inclusion Criteria

1. Participants with a histologically confirmed diagnosis of CLL/SLL based on the International Workshop on CLL (iwCLL) criteria:

  1. Treatment intolerance or failure during or after treatment with chemoimmunotherapy (CIT) and BTK inhibitors (BTKi) or
  2. Treatment intolerance or failure during or after treatment with BTKi for CIT-ineligible participants as assessed by the investigator.
  3. Participants who require treatment based on the iwCLL 2018 criteria
  4. Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 to 2
  5. Life expectancy of > 6 month

EXCLUSION CRITERIA

Key Exclusion Criteria

  1. Prior malignancy within the past 2 years, except for curatively treated basal or squamous cell skin cancer, superficial bladder cancer, carcinoma in situ of the cervix or breast, or low risk (Gleason score ≤ 6) localized prostate cancer
  2. Underlying medical conditions that, in the investigator's opinion, will render the administration of study drug hazardous or obscure the interpretation of safety or efficacy results
  3. A known history of or currently suspected Richter's syndrome
  4. Prior autologous stem cell transplant (unless ≥ 3 months after transplant) or prior chimeric cell therapy (unless ≥ 6 months after cell infusion)
  5. Prior allogeneic stem cell transplant

Note: Other protocol defined Inclusion/Exclusion criteria may apply

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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply


Contact the study center to learn if this study is a good match for you.
Phone iconCall 1.877.828.5568Email iconEmail Study Center

Study Details


Contition

Leukemia,Lymphoma,Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma,Small Lymphocytic Lymphoma,Relapsed Chronic Lymphocytic Leukemia

Age

18+

Phase

PHASE2

Participants Needed

97

Est. Completion Date

Aug 25, 2027

Treatment Type

INTERVENTIONAL


Sponsor

BeiGene

ClinicalTrials.gov NCT Identifier

NCT05479994

Study Number

BGB-11417-202

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