Herniorrhaphy for Postoperative Pain

Inclusion Criteria:

1. Able to sign Informed Consent
2. Scheduled to have inguinal hernia repair
3. Be a reasonably healthy adult 18 - 75 years of age
4. Body mass index ≤ 39 kg/m2
5. If biologically female, not pregnant or planning to become pregnant
6. If biologically male, using acceptable birth control
7. Be willing and able to complete study procedures

Exclusion Criteria:

1. Previously inguinal herniorrhaphy
2. Concurrent painful condition that may require analgesic treatment
3. History or clinical manifestation of significant medical, neuropsychiatric, or other condition, significant abnormal clinical laboratory test value, or known bleeding abnormality that could preclude or impair study participation
4. Clinically significant existing arrhythmia, bundle branch block or abnormal ECG, myocardial infarction, or coronary arterial bypass graft surgery within the prior 12 months
5. History of malignant hyperthermia or glucose-6-phosphate dehydrogenase deficiency.
6. Impaired liver function (e.g., alanine aminotransferase [ALT] > 3 × upper limit of normal [ULN] or total bilirubin > 2 × ULN), active hepatic disease, or cirrhosis.
7. Impaired renal function (e.g., creatinine > 1.5 × ULN).
8. Malignancy in the past year
9. Known or suspected daily use of opioids for 7 or more consecutive days within the previous 6 months.