AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2

Master Inclusion Criteria applicable to both sub studies:

1. Participant must be ≥ 18 years or the legal age of consent at the time of signing the ICF.
2. Participants who are CLDN18.2 positive.
3. Must have at least one measurable lesion according to RECIST v1.1.
4. ECOG performance status of 0 to 1 with no deterioration over the previous 2 weeks prior first day of dosing.
5. Predicted life expectancy of ≥ 12 weeks.
6. Adequate organ and bone marrow function as defined by protocol.
7. Body weight > 35 kg.
8. Participants are willing to comply with contraception requirements.

Sub study 1 Specific Inclusion criteria:

1. Histologically confirmed adenocarcinoma of the stomach or gastroesophageal junction.
2. Advanced or metastatic GC/GEJC.
3. Maximum 2 prior lines of systemic treatment for unresectable or metastatic disease.

Sub study 2 Specific Inclusion criteria:

1. Participants diagnosed with histologically confirmed metastatic or advanced PDAC.
2. Availability of an archival sample or a fresh tumour biopsy taken at screening.
3. No prior treatments for unresectable or metastatic disease.

Master Exclusion Criteria applicable to both sub studies:

1. Unstable or active peptic ulcer disease or digestive tract bleeding including but not limited to clinically significant bleeding in the setting of prior CLDN18.2 directed therapy.
2. Participants with clinically significant ascites that require drainage.
3. A history of drug-induced non-infectious ILD/pneumonitis.
4. Central nervous system metastases or CNS pathology.
5. Peripheral neuropathy ≥ Grade 2 at screening.
6. History of another primary malignancy.
7. Prior exposure to any MMAE-based ADC.
8. Prior exposure to any CLDN18.2 targeted agents except anti-CLDN18.2 monoclonal antibody.

Sub study 1 Specific Exclusion criteria:

1. Participants with HER2-positive (3+ by IHC, or 2+ by IHC, and positive by ISH) or indeterminate GC/GEJC.
2. Any factors that increase the risk of QTc prolongation or risk of arrhythmic events.
3. The use of concomitant medications known to prolong the QT/QTc interval.

Sub study 2 Specific Exclusion criteria:

1. Known DPD enzyme deficiency based on local testing where testing is SoC.
2. Use of strong inhibitor or inducer of UGT1A1.
3. Use of strong inhibitors or inducers of CYP3A4.